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Conference Coverage (NCVDG)

Merck HIV DNA Vaccine Protects Monkeys; Human Trials Begin

Published in AIDS Weekly, May 26th, 1997

Prime/boost vaccination using a new HIV DNA vaccine protected monkeys from infection with a chimeric simian/human immunodeficiency virus (SHIV).

The approach is now being tested in humans, reported Merck researcher Margaret A. Liu in a presentation to the 9th Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS (NCVDG), held May 4-7, 1997, in Bethesda, Maryland.

"The potent immunity and protection seen in these pilot experiments suggest that a DNA immunization with a DNA-plus-protein-boost regimen warrants active investigation as a vaccine strategy to prevent HIV-1 infection," Liu wrote in her presentation abstract.

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