Conference Coverage (NCVDG)

Vaccine Therapy Targets Antigens for CTL Attack

Published in AIDS Weekly, May 26th, 1997

A new type of vaccine vastly increases elimination of HIV infected cells by cytotoxic lymphocytes (CTLs).

The technique uses viral genes that have been altered so that the antigens they express are presented to the immune system far more efficiently than they are during normal virus replication. Such vaccines theoretically could be adapted to express altered antigens from other intracellular pathogens or tumor cells, and could be used to prevent or treat disease.

"A rapid and vigorous CD8⁺ CTL response, induced by vaccination, can, in principle, prevent disseminated infection in vaccinated individuals who are exposed to the relevant...

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Source: AIDS Weekly (1997-05-26)

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