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Uninfected Sex Partners: Saved by Mucosal Immunity to HIV?

Published in AIDS Weekly, June 2nd, 1997

Some people who didn't get HIV from unsafe sex may have been protected by it.

A study of heterosexual men and women who didn't get HIV infection despite repeated unprotected sex with their infected partner shows that most of them developed anti-HIV mucosal and cellular immune responses.

"Mucosal IgA may permit systemic penetration of only subinfectious doses of HIV," suggested former NIH researcher Mario Clerici, now with the University of Milan, Italy. "Low-dose 'immunization' [by sexual exposure] raised cell-mediated immunity."

Clerici discussed the study in a presentation to the 9th Annual Meeting of the National Cooperative...

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