"Bob" and "Bonzo": Monkey Business Points To HIV Coreceptors

The answer is expected to provide insight into an as-yet unanswered question about HIV infection: how do macrophage-tropic viral strains - which are responsible for the vast majority of sexual transmissions - infect T cells'

The answer may lie in monkey-cell receptors dubbed "bob" and "bonzo". These receptors (there are at least two, but no more than five) are expressed on rhesus monkey T cells and on some human T-cell lines and peripheral blood mononuclear cells (PBMCs). They apparently mediate T-cell infection by macrophage-tropic (M-tropic) viral strains independently of the CXCR4 coreceptor employed by...

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