Published in AIDS Weekly, June 9th, 1997
The answer is expected to provide insight into an as-yet unanswered question about HIV infection: how do macrophage-tropic viral strains - which are responsible for the vast majority of sexual transmissions - infect T cells'
The answer may lie in monkey-cell receptors dubbed "bob" and "bonzo". These receptors (there are at least two, but no more than five) are expressed on rhesus monkey T cells and on some human T-cell lines and peripheral blood mononuclear cells (PBMCs). They apparently mediate T-cell infection by macrophage-tropic (M-tropic) viral strains independently of the CXCR4 coreceptor employed by...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.