"Strong Augment Effect of IL-12 Expression Plasmid on the Induction of HIV-Specific Cytotoxic T Lymphocyte Activity by a Peptide Vaccine Candidate."

According to the authors' abstract of an article published in Clinical Immunology and Immunopathology, "We previously reported that repeated inoculation of VC1, a macromolecular multicomponent peptide vaccine emulsified with Freund's adjuvant (VC1-F), induced high cytotoxic T lymphocyte (CTL) levels and a substantial level of multivalent antibodies which neutralized various human immunodeficiency virus type 1 (HIV-1) isolates. In the present study, we report that inoculation of VC1-F plus interleukin (IL)-12 expression plasmid can induce a higher antigen-specific CTL response compared to that with VC1-F alone. VC1-F plus IL-12 expression plasmid or VC1-F alone were inoculated to BALB/c...

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