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Conference Coverage (SPIRAT/NCDDG-HIV)

IL-16 Enhances IL-2 CD4+ T-Cell Reconstitution

Published in AIDS Weekly, July 28th, 1997

Interleukin 16 (IL-16) corrects some of the functional defects seen in HIV infected cells.

The cytokine may thus have a therapeutic role in combination with IL-2, intermittent doses of which increase CD4+ T-cell counts in people with HIV infection.

"We hypothesize that IL-16 may be a useful adjunct to IL-2 for immune reconstitution therapy of HIV-1 infected individuals, increasing the number of CD4+ T cells while at the same time suppressing viral replication," suggested Nereida A. Parada and colleagues of the Boston University School of Medicine, Boston, Massachusetts.

Parada reported data from a study of...

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