Published in AIDS Weekly, August 11th, 1997
The novel, rational approach to new anti-HIV agents focuses on two zinc-binding domains of the HIV nucleocapsid p7 (NCp7) protein, which are extraordinarily well-conserved among viral strains. William G. Rice of the National Cancer Institute and colleagues have been developing compounds that attack the sulfur atoms of the cysteine residues that coordinate zinc binding (Rice et al., Nature, 1993;361:473-5; PNAS, 1993;90:9721-4; Science, 1995;270:1194-7; Antimic Ag Chem, 1997;41:419-26).
Meanwhile, M. Vandevelde...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.