"Expression Cloning of New Receptors Used by Simian and Human Immunodeficiency Viruses."

According to the authors' abstract of an article published in Nature, "Several members of the chemokine-receptor family serve, in conjunction with CD4, as receptors for the entry of human immunodeficiency virus type I (HIV-1) into cells. The principal receptor for entry of macrophage-tropic (M-tropic) HIV-1 strains is CCR5, whereas that for T-cell-line-tropic (T-tropic) strains is CXCR4. Unlike HlV-1, infection with either M-tropic or T-tropic strains of simian immunodeficiency virus (SIV) can be mediated by CCR5, but not CXCR4. SIV strains will also infect CD4⁺ cells that lack CCR5, which suggests that these strains use as yet unidentified receptors. Here we use an...

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