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AIDS Vaccines

MPL Improves Antibody Response to Naked DNA HIV Vaccine

Published in AIDS Weekly, September 15th, 1997

An experimental naked DNA HIV vaccine elicited anti-HIV antibodies in vastly higher quantities and of superior quality when administered with monophosphoryl lipid A (MPL) adjuvant.

"MPL has a strong adjuvant effect on DNA vaccination against HIV-1," concluded Shin Sasaki of Yokohama City University School of Medicine and colleagues, who reported their findings in the journal Infection and Immunity ("Monophosphoryl Lipid A Enhances Both Humoral and Cell-Mediated Immune Responses to DNA Vaccination against Human Immunodeficiency Virus Type 1," Infect Immune, 1997;65(9):3250-8).

DNA vaccination is very efficient at eliciting cell-mediated immunity...

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