Published in AIDS Weekly, September 22nd, 1997
Retroviral vectors have many uses, including stable gene transfection. A major drawback, however, is that at least one round of cell division is required for proviral integration into the target cells. These vectors cannot be used for gene transfer to nondividing or growth-arrested cells, so their usefulness is severely restricted. The use of HIV-1 as a vector would enable transfection into any of the cells that HIV-1 could normally infect, including quiescent cells and neurons.
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