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Candida albicans

Discovery of Genetic Pathways May Provide New Ways to Combat Fungal Infection

Published in AIDS Weekly, September 22nd, 1997

A new study has uncovered the genetic wiring diagram underlying the infectiousness of Candida albicans, a fungus that causes thrush in babies, vaginal infections in women, and life-threatening infections in chemotherapy and AIDS patients.

The study, led by Dr. Gerald R. Fink, director of the Whitehead Institute for Biomedical Research, reveals that one key to C. albicans' infectiousness lies in its ability to switch from a rounded form to filamentous forms. When the wiring diagram underlying this switch is inactivated, Candida infections are no longer deadly in mice.

The implications of these results for humans are enormous,...

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