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Costimulatory DNA Modulates Immune Response to DNA Vaccines

Published in AIDS Weekly, September 29th, 1997

DNA encoding the costimulatory molecule CD86 can be used to manipulate the strength and type of immune responses to DNA vaccines.

"We observed a dramatic increase in cytotoxic T-lymphocyte [CTL] induction as well as T-helper-cell proliferation with the co-administration of genes for CD86 [with HIV-1 DNA immunization cassettes]," reported Jong J. Kim of the University of Pennsylvania, Philadelphia.

Kim reported the findings in a presentation to the first annual International Society for Vaccines Symposium on Vaccinology, held September 8-11, 1997, in Leesburg, Virginia.

The main focus on induction of cellular immunity is the...

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