DNA Vaccines (HIV)

Addition of Env Protein Boosts Antibody Response in HIV DNA Study

Published in AIDS Weekly, October 6th, 1997

Addition of HIV-1 Env protein to a plasmid-encoded HIV-1 env DNA vaccine during the booster phase elicited potent and protective anti-HIV immune responses in a pilot study of rhesus monkeys.

An effective vaccine against any disease should elicit both strong neutralizing antibody and cytotoxic T lymphocyte (CTL) responses. Several recent studies have demonstrated the utility of plasmid DNA immunization in the induction of virus-specific CTL responses in animal models, and it is speculated that it might prove a useful vaccine modality against HIV.

In previous research, Normal L. Letvin, Margaret A. Liu, and colleagues from Beth Israel Hospital...

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Source: AIDS Weekly (1997-10-06)

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