Published in AIDS Weekly, October 6th, 1997
An effective vaccine against any disease should elicit both strong neutralizing antibody and cytotoxic T lymphocyte (CTL) responses. Several recent studies have demonstrated the utility of plasmid DNA immunization in the induction of virus-specific CTL responses in animal models, and it is speculated that it might prove a useful vaccine modality against HIV.
In previous research, Normal L. Letvin, Margaret A. Liu, and colleagues from Beth Israel Hospital...
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