Blood Banking (Photodecontamination)
"Psoralen-Mediated Photodecontamination of Platelet Concentrates: Inactivation of Cell-Free and Cell-Associated Forms of Human Immunodeficiency Virus and Assessment of Platelet Function in vivo. DOUBLEQUO
Published in AIDS Weekly, October 27th, 1997
According to the authors' abstract of an article published in Transfusion, "Background: Treatment of platelet concentrates (PCs) with psoralens and broad-band ultraviolet A (UVA) radiation is being examined for the elimination of pathogens that might be present in donated blood. Previous studies have demonstrated the inactivation of cell-free viruses and the maintenance of platelet integrity with common in vitro assays. Study Design and Methods: Human immunodeficiency virus (HIV) in three forms - cell-free, actively replicating, and latently infected cell lines - was added to PCs and treated with 50 (mu)g per mL of 4'-aminomethyl-4,5',8-trimethylpsoralen (AMT), 0.35 mM...
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Source: AIDS Weekly (1997-10-27)
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