"Induction of Mucosal and Systemic CTL and Protective Immunity Against Intra-Rectal Recombinant Vaccinia Challenge in Mice by Mucosal Immunization with HIV-1 Peptide Vaccine."

According to an abstract submitted by the authors to the conference HIV-1 Infection, Mucosal Immunity and Pathogenesis, held September 11-13, 1997, at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland, "This study makes the novel observation that a synthetic multideterminant HIV peptide vaccine can induce an antigen-specific CTL response in the mucosal immune system. Intra-rectal (JR) immunization with the synthetic HIV peptide vaccine PCLUS3-18IIIB and cholera toxin (CT), induced P18IIIB HIV-1 envelope-peptide-specific CTL in both the inductive (Peyer's patch) and the effector (lamina propria) sites of the mucosal immune system, as well as in systemic...

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