Anemia Gene Therapy

Clinical Trial for Erythropoietin-Responsive Anemia One Step Closer

Published in AIDS Weekly, November 17th, 1997

Long-term erythropoietin (Epo) expression mediated via a replication-defective adenoviral vector was possible in both an immunocompetent murine model and non-human primate model.

Epo is a cytokine that functions as the major regulator of red blood cell (RBC) production by mammalian bone marrow. In human adults, Epo is produced in the kidney and under hypoxic or anemic conditions, is secreted into the systemic circulation.

When it reaches the bone marrow, Epo stimulates RBC production by enhancing the proliferation of, and preventing the apoptosis of, RBC precursors, including both erythroid burst-forming units (BFU-E) and erythroid colony-forming...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of AIDS Weekly

Source: AIDS Weekly (1997-11-17)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry