Published in AIDS Weekly, November 17th, 1997
Epo is a cytokine that functions as the major regulator of red blood cell (RBC) production by mammalian bone marrow. In human adults, Epo is produced in the kidney and under hypoxic or anemic conditions, is secreted into the systemic circulation.
When it reaches the bone marrow, Epo stimulates RBC production by enhancing the proliferation of, and preventing the apoptosis of, RBC precursors, including both erythroid burst-forming units (BFU-E) and erythroid colony-forming...
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