Pathogenesis

HIV Replication Continues Even During Successful HAART

Published in AIDS Weekly, December 22nd, 1997

The finding that HIV replication continues even during successful highly active antiretroviral therapy (HAART) dashes hopes that the combination treatment could cure AIDS.

Most patients able to comply with HAART regimens see their plasma HIV loads drop to undetectable levels. It had been hoped that this meant HIV replication had been halted by the powerful combination of drugs that deliver a one-two punch to the replication machinery of the virus.

With replication halted, mathematical formulae show that the virus could be eliminated within 2.3 to 3.1 years (Perelson, A.S. et al., Nature, 1997;387:188-91).

The first evidence that...

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Source: AIDS Weekly (1997-12-22)

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