Pathogenesis

Study Suggests Gene Can Let HIV Escape Body's Defenses

Published in AIDS Weekly, February 9th, 1998

Scientists might have found one way HIV evades the body's defenses: a single HIV gene can apparently keep infected cells from declaring that they harbor the virus.

If doctors can find drugs that hamper the gene's cloaking effect, it might help control HIV infections, the test-tube study suggests.

Normally, when a virus infects a cell, the cell displays bits of viral proteins on its surface like red flags to alert the immune system. The system can then kill the cell, keeping the virus from replicating.

But HIV appears to interfere with that warning system by the action of a gene called nef. The protein resulting from that...

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Source: AIDS Weekly (1998-02-09)

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