AIDS Drugs

Critical HIV Structure Solved

Published in AIDS Weekly, February 9th, 1998

Solution of a critical HIV structure - conserved in all strains - strengthens a new line of attack on the virus.

The critical structure, part of the virus's p7 nucleocapsid (NC) protein, is required for zinc binding to the so-called viral CCHC-type zinc fingers or zinc knuckles.

These structures are so important that nearly all retroviral NC have one or two of these structures. Compounds that abolish zinc binding in this region prevent viral replication. Two such compounds, identified as zinc ejectors only after their anti-HIV activities had been detected, already are in clinical trials.

"Our studies provide the basis for an...

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Source: AIDS Weekly (1998-02-09)

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