"Enhancement of MHC Class I-Restricted Peptide-Specific T-Cell Induction by a DNA Prime MVA Boost Vaccination Regime."

According to the authors' abstract of an article published in Vaccine, "Human immunodeficiency virus (HIV) vaccine candidates were previously constructed as a string of cytotoxic T lymphocyte (CTL) epitopes delivered and expressed using DNA and modified virus Ankara (MVA; an attenuated vaccinia virus) vectors. These vaccines were shown to induce interferon (IFN)-gamma-producing and cytolytic CD8⁺ T cells after a single vaccine administration. In the course of this work, immunization protocols were sought which would improve the levels of induced HIV specific T cells. It was found that previous immunological exposure to MVA reduced the efficiency of subsequent priming and...

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