Vector Development

HIV-1 Nef Pseudotyped with Vesicular Stomatitis Virus Enhances Infectivity

Published in AIDS Weekly, April 27th, 1998

HIV Nef particles pseudotyped with the vesicular stomatitis virus (VSV) could have implications for HIV based gene transfer systems.

Because lentiviruses can transduce nondividing cells, there has been a growing interest in developing lentivirus-based gene transfer systems. However, HIV-1, the lentivirus most often used for this purpose, presents many challenges to the establishment of efficient gene transfer systems.

Tianci Luo and a team of researchers from the St. Jude Children's Research Hospital, Tennessee, presented data showing intrinsic differences between the infectivity of wild-type HIV and HIV particles pseudotyped with heterologous...

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Source: AIDS Weekly (1998-04-27)

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