Published in AIDS Weekly, April 27th, 1998
Because lentiviruses can transduce nondividing cells, there has been a growing interest in developing lentivirus-based gene transfer systems. However, HIV-1, the lentivirus most often used for this purpose, presents many challenges to the establishment of efficient gene transfer systems.
Tianci Luo and a team of researchers from the St. Jude Children's Research Hospital, Tennessee, presented data showing intrinsic differences between the infectivity of wild-type HIV and HIV particles pseudotyped with heterologous...
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