Kaposi's sarcoma

"Fumagillin Analog in the Treatment of Kaposi's sarcoma: A Phase I AIDS Clinical Trial Group Study."

Published in AIDS Weekly, May 18th, 1998

According to the authors' abstract of an article published in Journal of Clinical Oncology, "Purpose: Angiogenesis is a major component of Kaposi's sarcoma (KS) and a critical process in tumor growth. The present study was designed primarily to test the toxicity and pharmacokinetics (PK) of the angiogenesis inhibitor TNP-470 and secondarily to evaluate tumor response in patients with early AIDS-related KS. Patients and Methods: Patients with AIDS-related KS were required to have cutaneous disease with greater than or equal to 5 measurable lesions and no evidence of pulmonary, symptomatic gastrointestinal, or acutely life-threatening KS. Thirty-eight patients received...

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Source: AIDS Weekly (1998-05-18)

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