Autoimmunity

Breakthrough in Immune Tolerance

Published in AIDS Weekly, May 18th, 1998

The discovery of a unique marker that identifies anergic T cells now makes possible the direct study of a major aspect of immunity.

Induction of T-cell anergy is thought to be a major process in preventing the immune system from attacking normal self cells. The process also is implicated in the lack of response to several viral and bacterial pathogens.

Such pathogens produce superantigens capable of making the immune system tolerant of non-self antigens. Researchers have discovered that they can use superantigens to experimentally induce anergy, but there has been no way to purify anergic T cells for further study.

Now Curtis C....

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Source: AIDS Weekly (1998-05-18)

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