"Lymphatic Endothelium and Kaposi's sarcoma Spindle Cells Detected by Antibodies Against the Vascular Endothelial Growth Factor Receptor-3."

According to the authors' abstract of an article published in Cancer Research, "Lymphatic vessels have been difficult to study in detail in normal and tumor tissues because of the lack of molecular markers. Monoclonal antibodies against the extracellular domain of the vascular endothelial growth factor-C receptor that we have named VEGFR-3 were found to specifically stain endothelial cells of lymphatic vessels and vessels around tumors such as lymphoma and in situ breast carcinoma. Interestingly, the spindle cells of several cutaneous nodular AIDS-associated Kaposi's sarcomas and the endothelium around the nodules were also VEGFR-3 positive. The first specific molecular marker for the...

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