AIDS Dementia Complex (Therapy)

Drug Options Available for Patients Who Cannot Take Zidovudine

Published in AIDS Weekly, June 8th, 1998

HIV-1 disease involves the central nervous system shortly after infection. The viral RNA replicates in the cerebrospinal fluid and eventually can lead to a form of dementia called AIDS dementia complex.

Zidovudine has been shown to decrease the number of cases of AIDS dementia complex. Now, in a new study, Dr. Norbert Foudraine and colleagues from The Netherlands investigated how well two combinations of drugs - lamivudine and stavudine, or lamivudine and zidovudine - penetrated the cerebrospinal fluid, in which the RNA replicates, and how the drugs affected the numbers of copies of RNA present. They presented their work in the Lancet (May 23,...

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Source: AIDS Weekly (1998-06-08)

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