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Kaposi's sarcoma

"Prospective Randomized Trial of Two Dose Levels of Interferon alfa With Zidovudine for the Treatment of Kaposi's Sarcoma Associated With Human Immunodeficiency Virus Infection: A Canadian HIV Clinical Trials Network St

Published in AIDS Weekly, June 22nd, 1998

According to the authors' abstract of an article published in Journal of Clinical Oncology, "Purpose: Interferon alfa alone has shown antitumor activity against Kaposi's sarcoma (KS), and Phase I and II clinical trials showed that interferon and zidovudine could be administered safely to patients with human immunodeficiency virus (HIV)-associated KS. These observations led to our trial of zidovudine with two dose levels of interferon alfa. Methods: HIV positive patients with KS were eligible if they were older than 18 years of age, had a performance status of 0 to 2, and were free of active infection. All patients received zidovudine 500 mg daily and were randomized to...

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