Vaccine Development
Nasal Route Better Than Muscular Route for HIV-1 DNA Vaccine
Published in AIDS Weekly, July 27th, 1998
A Japanese study suggests that the intranasal route of vaccine administration may offer superior efficacy in such a vaccine ("Induction of Systemic and Mucosal Immune Responses to HIV-1 by a DNA Vaccine Formulated with QS-21 Saponin Adjuvant Via Intramuscular and Intranasal Routes," Journal of Virology, June 1998;72(6):4931-4939).
Induction of mucosal and cell-mediated immunity is critical for development of an effective vaccine against HIV.
In this study, S. Sasaki and colleagues compared intramuscular and intranasal immunizations...
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Source: AIDS Weekly (1998-07-27)
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