Conference Coverage (12th World AIDS)
HIV Tat Selects Infecting Viral Variant
Published in AIDS Weekly, August 10th, 1998
This seeming contradiction provides an answer to the long-standing question of exactly why, when a transmitting individual carries both T-cell-tropic (T-tropic) and macrophage-tropic (M-tropic) HIV strains, only the M-tropic virus is transmitted.
"There really are two effects of Tat," said Kuan-Teh Jeang of the National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. "At low concentrations, there is blocking of infectivity. At high concentrations, increased transactivation overrides this inhibition. But that only happens...
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Source: AIDS Weekly (1998-08-10)
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