Published in AIDS Weekly, August 10th, 1998
The hypothesis explains the various disfiguring side effects (distended abdomen, buffalo hump on the back of the neck, enlarged breasts in women, wasting in the face and limbs) and metabolic events (diabetes, increased bleeding in hemophiliacs, hyperlipidemia) reported by patients receiving protease inhibitors as part of highly active antiretroviral therapy (HAART).
These disturbing side effects may lead physicians to avoid the use of PIs in asymptomatic patients. For symptomatic patients, the drug toxicities are not nearly as devastating as HIV...
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