Published in AIDS Weekly, August 10th, 1998
To gain entry into the host cell, HIV has expropriated chemokine receptors. M- and T-tropic viruses use CCR5 and CXCR4 as co-receptors, respectively. This subjects the virus to suppression by the natural ligand of these receptors. As such, C-C ((beta)) and C-X-C ((alpha)) chemokines inhibit HIV infection, possibly by interfering with the binding of the viral envelope to the co-receptor.
Because the mechanism of this three component interaction: natural ligand (chemokine), bandit ligand (viral...
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