"Efficient Expression of Anti-HIV Genes in Primary T Cells and Monocytes Using Scaffold Attachment Region-Encoding Retroviral Vectors."

According to an abstract submitted by the authors to the 27th Annual Meeting of the International Society for Experimental Hematology, held August 1-5, 1998, in Vancouver, British Columbia, Canada, "As a part of our efforts to develop hematopoietic stem/progenitor cells (HSPC)-based gene therapies for HIV disease we have studied retroviral vector expression in human CD34⁺ HSPC, and T and myeloid cells derived from transduced HSPC in various in vitro and in vivo assays (SCID-hu models). In general, retroviral vectors were efficiently expressed in HSPC few days after transduction but the expression in differentiated cells was less efficient and depended on activation (for T...

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