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Kaposi Sarcoma

Tat Stimulation Activates Signal Transduction Pathways

Published in AIDS Weekly, October 5th, 1998

The HIV gene product Tat activates signaling molecules that may be associated with growth of Kaposi sarcoma (KS) cells.

"The characterization of the Tat-induced signal transduction pathway in KS may provide insights into developing targeted therapies to inhibit its growth and spread," wrote Ramesh K. Ganju, Harvard Institutes of Medicine, and colleagues ("Human Immunodeficiency Virus Tat Modulates the Flk-1/KDR Receptor, Mitogen-Activated Protein Kinases, and Components of Focal Adhesion in Kaposi's Sarcoma Cells," Journal of Virology, 1998;72:6131-6137).

KS spindle cell growth and spread have been reported to be modulated by various cytokines as...

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