"Development of an EPLC Method for the Determination of L-756,423, a Novel HIV Protease Inhibitor, in Human Plasma and Urine."

According to an abstract submitted by the authors to the 1998 Annual Meeting of the American Association of Pharmaceutical Scientists, held November 15-19, 1998, in San Francisco, California, "Purpose: Development of an HPLC method for the determination of L-756,423 (I) from human plasma and urine. Methods: Various detection methods were examined including W, fluorescence and mass spectrometry. The highly basic nature of I and the internal standard (II) necessitated a study of the chromatographic behavior of these compounds on several base-deactivated HPLC packings. Different methods of plasma and urine preparation were compared including liquid/liquid extraction using...

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