Mucosal Immunization

"Increase in Plasma Viral Load After Oral Cholera Immunization of HIV Infected Subjects."

Published in AIDS Weekly, November 23rd, 1998

According to the authors' abstract of an article published in AIDS, "Objective: Constant antigenic stimulation of the large immune cell population contained within-gut-associated lymphoid tissue during HIV infection may contribute to patients' total viral load. The aim of this investigation was to evaluate the effect of a mucosal antigenic challenge on HIV replication. Design: Prospective clinical study. Methods: Twelve HIV-1 infected men (mean age, 42.3 years) from the Casa de Apoio Santo Antonio, Rio de Janeiro, Brazil, were immunized with combined whole cell-toxin B subunit oral cholera vaccine. Blood was collected on days 0, 2, 4, 6, 10, and 15 after...

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Source: AIDS Weekly (1998-11-23)

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