Immunology

T-Cell Dimmer Switch Identified In Vivo

Published in AIDS Weekly, December 7th, 1998

Do most T-cell receptors (TCRs) act as on/off switches or as dimmer switches'

Science is now on the verge of a major breakthrough in understanding the regulation of cellular immunity. Ligands capable of partially activating T cells - known as altered peptide ligands (APL), TCR partial agonists, or TCR antagonists - have for the first time been demonstrated in vivo.

Whether such ligands play a major or minor role in cellular immunity remains to be seen, but the new findings move this field of inquiry out of culture dishes and into animal models.

"These results unequivocally demonstrate in vivo antagonism by an endogenous APL and...

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Source: AIDS Weekly (1998-12-07)

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