Disease Associations

Hypothesis Presented on How AIDS-Related Dementia Develops

Published in AIDS Weekly, December 14th, 1998

Poisons released by dying astrocytes - cells that normally nourish nerve cells and detoxify the brain - could solve the mystery of AIDS dementia.

One in five people with AIDS eventually develops dementia. The mystery is that HIV does not appear to infect nerve cells. Until now, the leading hypothesis has been that AIDS dementia is due to the virus infecting microglia, a type of immune cell found only in the brain, which can produce toxic biochemicals such as quinolinic acid.

But a research team from Flinders University in Bedford Park, South Australia, and Johns Hopkins University in Baltimore, Maryland, recently discovered that HIV also can infect...

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Source: AIDS Weekly (1998-12-14)

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