Mucosal Immunity

Best Mucosal Responses Seen At Site of Immunization

Published in AIDS Weekly, December 14th, 1998

Despite the ability of mucosal delivery to induce very good systemic responses to vaccination, the best mucosal immune responses are local.

The findings, from studies of cynomolgus monkeys, suggest how vaccines against sexually transmitted diseases - including AIDS - might best be administered.

"Local administration of antigen to the rectal or vaginal mucosa results in higher ASC [antibody-secreting cell] responses than systemic or distant mucosal delivery," observed Kristina Eriksson and colleagues of the University of Goteborg, Sweden. "Furthermore, both the vaginal and the rectal mucosae can serve as inductive sites for systemic ASC...

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Source: AIDS Weekly (1998-12-14)

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