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Transmission (Vertical)

Deaths Prompt Concern Over HIV Drug Combinations

Published in AIDS Weekly, February 15th, 1999

The death of two children in a French AIDS study has raised possible concerns about drug combinations used to prevent HIV infected mothers from passing the virus to their babies during birth.

The use of the drug AZT to stop mother-to-child transmission of HIV often is cited as one of the greatest successes in efforts against AIDS. The drug can halve the risk of vertical transmission of HIV, which is typically around 20 percent to 25 percent. Since AZT's benefits in this area were shown five years ago, doctors in the United States and France largely have switched to using AZT in combination with 3TC, a similar AIDS drug, for pregnant women.

Dr....

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