Pathology
"Virus Replication Begins in Dendritic Cells During the Transmission of HIV-1 from Mature Dendritic Cells to T Cells."
Published in AIDS Weekly, February 22nd, 1999
According to the authors' abstract of an article published in Current Biology, "Background: To initiate immunity, dendritic cells (DCs) capture antigens or viruses at body surfaces, undergo maturation to express T-cell costimulatory molecules, and then migrate to lymphoid organs. DCs at body surfaces can capture human immunodeficiency virus 1 (HIV-1), but mature DCs do not support replication of the virus unless T cells are added. The initial site for HIV-1 replication remains unknown and it is unclear whether replication can take place in DCs or whether the virus must first be transmitted from DCs to T cells. Results: We generated mature DCs from monocyte precursors. ...
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Source: AIDS Weekly (1999-02-22)
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