Published in AIDS Weekly, February 22nd, 1999
The suggestion comes from a study of a single family of macaque monkeys experimentally infected with SIVmac251, a pathogenic strain of simian immunodeficiency virus (SIV).
Two of the animals rapidly progressed to disease, both had identical major histocompatibility complex (MHC) class 1 alleles. They differed from two slow progressors only by a single MHC class 1 haplotype.
"Remarkably, this haplotype was shared by both slow progressors, and encoded two molecules used to present three different CTL [cytotoxic lymphocyte] epitopes...
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