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Conference Coverage (Retrovirus)

Ex-Vivo-Expanded CTL Home In On Lymph-Node HIV

Published in AIDS Weekly, March 15th, 1999

It's one step back, two steps forward for a promising AIDS immunotherapy.

The idea seems simple: since HIV specific cytotoxic lymphocytes (CTLs) appear to be important in fighting the virus, why not expand a patient's CTL ex vivo and return them to the scene of the crime'

What actually happens is unexpectedly complex. But new data from human trials suggest that a useful application may at last be just around the corner.

"We know these cells made it to the lymph node. We know they aggregated there," said University of Washington researcher Scott J. Brodie in a presentation to the 6th Conference on Retroviruses and Opportunistic...

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