"Influence of Detection of HIV Mutants with Resistances to RTI on Therapeutic Choices and Clinical Outcome in a Cohort of HIV⁺ Individuals."

According to an abstract submitted by the authors to the International Conference on the Discovery and Clinical Development of Antiretroviral Therapies, held December 13-17, 1998, in St. Thomas, West Indies, US Virgin Islands, "Three major interdependent issues can negatively influence the outcome of HAART with two RTI and one PI, otherwise shown to be strongly efficient in reducing HIV replication to undetectable levels: poor patients' compliance, difficulty in maintaining body fluid drug concentrations above activity thresholds and viral drug resistances. The first can never be assessed before therapy administration, although considerations on patients' characteristics and drug...

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