Sexual Transmission

Natural Product Candidate for Vaginal Virucide

Published in AIDS Weekly, May 17th, 1999

A highly durable natural product could become the basis for a vaginal microbicide to prevent HIV transmission.

The product is the small (11 kDa) protein cyanovirin-N (CV-N). It was originally isolated at the U.S. National Institutes of Health (NIH) from the cyanobacterium Nostoc ellipsosporum during a search for natural products with anti-HIV activity.

Without loss of antiviral activity, CV-N can resist physiochemical degradation. It can withstand treatment with denaturants, detergents, organic solvents, multiple cycles of freezing and thawing, and heat up to 100(degree)C.

CV-N is known to target the HIV gp120 envelope...

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Source: AIDS Weekly (1999-05-17)

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