Virology
"Identification of Determinants of Interaction Between CXCR4 and gp120 of a Dual-Tropic HIV-1(DH12) Isolate."
Published in AIDS Weekly, July 26th, 1999
According to the authors' abstract of an article published in Virology, "Using a panel of chimeric viruses and their chimeric envelope glycoproteins, we have previously reported that the V1/V2 or the V3 regions of a dual-tropic primary human immunodeficiency virus type 1 (HIV-1) isolate (HIV-1(DH12)) could individually confer CXCR4 usage when introduced into the backbone of a macrophage-tropic (M-tropic) virus isolate (HIV-1(ADS)). In this study, chimeric CXCR4-CXCR2 chemokine receptors were employed to identify the determinants involved in the interaction between CXCR4 and the dual-tropic HIV-1(DH12) gp120. Our results indicate that (i) HIV-1(DH12) gp120 interacts primarily with the...
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Source: AIDS Weekly (1999-07-26)
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