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AIDS Vaccines

Gallo: HIV Vaccines Should Include Tat Toxoid

Published in AIDS Weekly, August 16th, 1999

AIDS pioneer Robert C. Gallo says AIDS vaccines should include inactivated Tat toxoid, an antigen capable of inducing antibodies against the HIV Tat protein.

Preliminary results from studies already underway at Gallo's Institute of Human Virology indicate that the chemically detoxified toxin is safe and immunogenic in healthy human volunteers.

The immunogen could be used both to treat and to prevent HIV infection, Gallo suggested.

"In my view, a 'detoxified' Tat will be an important component of a prophylactic or therapeutic vaccine coupled with a vector delivery of HIV-1 structural proteins," Gallo wrote. "Such a composite...

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