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Immunology
"beta-Chemokine Production in Macaques Vaccinated With Live Attenuated Virus Correlates With Protection Against Simian Immunodeficiency Virus (SIVsm) Challenge."
August 23rd, 1999
According to the authors' abstract of an article published in Journal of General Virology, "Simian immunodeficiency virus (SIV) uses the CCR5 chemokine receptor as the main co-receptor to enter CD4+ cells. RANTES, MIP-1 alpha and MIP-1 beta have been suggested as the major human immunodeficiency virus-suppressor factors produced by CD8+ T cells. The aim of this study was to investigate the CD8+ T-cell production of antiviral factors and of beta-chemokines in six cynomolgus macaques vaccinated with live attenuated SIVmacC8 in relation to protection against infectious intrarectal SIVsm challenge. Three of the vaccinated animals were completely protected...
Source: AIDS Weekly (1999-08-23)
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