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Vaccine Development
"Design of Attenuated Recombinant Salmonella typhimurium Strains Producing HIV and HBV Antigens."
August 23rd, 1999
According to an abstract submitted by the authors to the 10th Symposium on HIV Infection, held June 17-19, 1999, in Toulon, France, "The aim of this study is construction of HIV and HBV vaccines using an attenuated Salmonella as vaccine carriers. The recombinant strains producing TBI (artificial protein which contains T- and B-cell epitopes of HIV), HBcAg, and chimeric core protein exposing on their surface the major immunogenic epitope of HBsAg (HBcAg-H-Bs) were constructed on the base of attenuated S. typhimurium strains. It was demonstrated that obtained Salmonella strains produced proteins which are able to self-assemble into the virus-like particles and display...
Source: AIDS Weekly (1999-08-23)
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