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Novel Therapeutics
Door Opens for Genetic Manipulation of the Brain
August 23rd, 1999
Neural stem cells (NSC) can safely carry retrovirus-vectored genes to multiple cell types within the central nervous system (CNS). This revolutionary suggestion comes from a team of researchers working on a seemingly unrelated question. William P. Lynch of Northeastern Ohio Universities College of Medicine and colleagues set out to resolve the question of whether a retroviral envelope (env) gene could by itself cause neurodegeneration. In the course of discovering that the answer is "no," Lynch et al. showed that brain-implanted NSCs can deliver retroviral genes directly to microglial cells within the brain. "The...
Source: AIDS Weekly (1999-08-23)
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