Drug Resistance

Researchers Discover Genetic Reason Why Some Patients Resist Therapy

Published in AIDS Weekly, September 6th, 1999

The gene MRP4 appears to help T cells, key components of the human immune system, "pump out" certain anti-HIV drugs and may allow the development of drug-resistant strains of HIV, reported a team of St. Jude Children's Research Hospital, Memphis, Tennessee, scientists in the September 1999 issue of Nature Medicine.

"We have found a significant clue to explain why some HIV infected patients resist therapy even when they have no detectable levels of drug-resistant strains of the virus," said John Schuetz, PhD, St. Jude pharmaceutical sciences and principal investigator of the study.

Resistance to nucleoside drugs, which are the backbone of anti-HIV...

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Source: AIDS Weekly (1999-09-06)

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