AIDS Therapies

HIV Rebounds after Stopping IL-2, Combination Antiretroviral Drug Therapy

Published in AIDS Weekly, November 8th, 1999

Rebound of HIV and reappearance of HIV reservoirs occurred in patients treated with IL-2 and combination antiretroviral drugs following cessation of therapy.

In two HIV infected patients treated with potent combinations of anti-HIV drugs and interleukin-2 (IL-2), and in whom even highly sensitive tests could detect no viable HIV, the virus quickly rebounded to substantial levels when therapy was stopped, according to researchers at the U.S. National Institute of Allergy and Infectious Diseases (NIAID).

NIAID director Anthony S. Fauci, MD, Tae-Wook Chun, PhD, and their colleagues reported their data in the October 28, 1999, issue of Nature.

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Source: AIDS Weekly (1999-11-08)

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